Cracked lips and soresin the corners of the mouth.
saliva
Decongestants
Pseudoephedrine, Phenylephrine
Reduce secretions including saliva
Antidepressants (TCAs, SSRIs)
Amitriptyline, Fluoxetine, Sertraline
Anticholinergic effects suppress salivary glands
Antipsychotics
Olanzapine, Clozapine, Haloperidol
Strong anticholinergic activity
Blood Pressure Medications
Amlodipine, Atenolol, Hydrochlorothiazide
Diuretic effect leads to dehydration
Diuretics
Furosemide, Spironolactone
Increase fluid loss, reducing saliva
Muscle Relaxants
Cyclobenzaprine, Baclofen
Anticholinergic side effects
Bladder Medications
Oxybutynin, Solifenacin
Specifically designed to reduce secretions
Parkinson’s Medications
Trihexyphenidyl, Benztropine
High anticholinergic activity
Important: If you take any of these medications and experience dry mouth, do not stop your medication without medical advice. Speak to your prescribing doctor about possible alternatives or dosage adjustments. Your dentist can help manage the oral health consequences.
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Dry Mouth at Night
Many people experience dryness of mouth specifically during sleep or upon waking, and the nighttime environment has its own set of triggers distinct from daytime dryness.